Deducing the conformational space for an octa-proline helix.

ABSTRACT: A molecular dyad, PY-P₈-PER, comprising a proline octamer sandwiched between pyrene and perylene terminals has been synthesized in order to address the dynamics of electronic energy transfer (EET) along the oligo-proline chain. A simple pyrene-based control compound equipped with a bis-proline attachment serves as a reference for spectroscopic studies. The N-H NMR signal at the terminal pyrene allows distinction between cis and trans amides and, although the crystal structure for the control has the trans conformation, temperature-dependent NMR studies provide clear evidence for trans/cis isomerisation in D₆-DMSO. Polar solvents tend to stabilise the trans structure for the pyrene amide group, even for longer oligo-proline uni

SUBMITTER: Waly SMA 

PROVIDER: S-EPMC10829019 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature