Risk for Chronic Kidney Disease Progression After Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort Study.

ABSTRACT:

Background

Prior studies associating acute kidney injury (AKI) with more rapid subsequent loss of kidney function had methodological limitations, including inadequate control for differences between patients who had AKI and those who did not.

Objective

To determine whether AKI is independently associated with subsequent kidney function trajectory among patients with chronic kidney disease (CKD).

Design

Multicenter prospective cohort study.

Setting

United States.

Participants

Patients with CKD (n = 3150).

Measurements

Hospitalized AKI was defined by a 50% or greater increase in inpatient serum creatinine (SCr) level from nadir to peak. Kidney function trajectory was assessed using estimated glomerular filtration rate (eGFR) based on SCr leve

SUBMITTER: Muiru AN 

PROVIDER: S-EPMC10829039 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature