Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family.

ABSTRACT:

Background

A chicken egg contains several biotin-binding proteins (BBPs), whose complete DNA and amino acid sequences are not known. In order to identify and characterise these genes and proteins we studied chicken cDNAs and genes available in the NCBI database and chicken genome database using the reported N-terminal amino acid sequences of chicken egg-yolk BBPs as search strings.

Results

Two separate hits showing significant homology for these N-terminal sequences were discovered. For one of these hits, the chromosomal location in the immediate proximity of the avidin gene family was found. Both of these hits encode proteins having high sequence similarity with avidin suggesting that chicken BBPs are paralogous to avidin family. In particular, almost all residues correspon

SUBMITTER: Niskanen EA 

PROVIDER: S-EPMC1082904 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature