Microwave ablation enhances the systemic immune response in patients with lung cancer.

ABSTRACT: Microwave ablation (MWA) is a key alternative therapy to conventional surgery for the treatment of lung cancer. In addition to eliminating local tumors, MWA may promote antitumor immunological responses, such as abscopal effects in distant lesions. However, the intensity of MWA is limited and the underlying mechanisms are not well-defined. The present study assessed the impact of MWA on immune cell subsets and cytokines in patients with lung cancer. A total of 45 patients with lung cancer who underwent percutaneous lung tumor MWA were enrolled. Peripheral blood samples were collected before and 24 h after MWA and changes in immune cell subsets [lymphocytes, CD3⁺, CD4⁺ and CD8⁺ T cells, B cells and natural killer (NK) cells] and serum cytokine levels (IL-1β,

SUBMITTER: Ma F 

PROVIDER: S-EPMC10829076 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature