Urine biomarkers individually and as a consensus model show high sensitivity and specificity for detecting UTIs.

ABSTRACT:

Background

Current diagnoses of urinary tract infection (UTI) by standard urine culture (SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the ability to identify organisms in polymicrobial infections. The significant rate of both SUC "negative" or "mixed flora/contamination" results in UTI cases and the high prevalence of asymptomatic bacteriuria indicate the need for an accurate diagnostic test to help identify true UTI cases. This study aimed to determine if infection-associated urinary biomarkers can differentiate definitive UTI cases from non-UTI controls.

Methods

Midstream clean-catch voided urine samples were collected from asymptomatic volunteers and symptomatic subjects ≥ 60 years old diagnosed with a UTI in a urology specialt

SUBMITTER: Akhlaghpour M 

PROVIDER: S-EPMC10829179 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature