Norepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via α_2A-adrenergic receptor.

ABSTRACT:

Background

The cochlear sympathetic system plays a key role in auditory function and susceptibility to noise-induced hearing loss (NIHL). The formation of reactive oxygen species (ROS) is a well-documented process in NIHL. In this study, we aimed at investigating the effects of a superior cervical ganglionectomy (SCGx) on NIHL in Sprague-Dawley rats.

Methods

We explored the effects of unilateral and bilateral Superior Cervical Ganglion (SCG) ablation in the eight-ten weeks old Sprague-Dawley rats of both sexes on NIHL. Auditory function was evaluated by auditory brainstem response (ABR) testing and Distortion product otoacoustic emissions (DPOAEs). Outer hair cells (OHCs) counts and the expression of α_2A-adrenergic receptor (AR) in the rat cochlea using immunofluo

SUBMITTER: Tian C 

PROVIDER: S-EPMC10829207 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature