Comparison of PET tracing and biodistribution between ⁶⁴Cu-labeled micro-and nano-polystyrene in a murine inhalation model.

ABSTRACT:

Introduction

Recent studies showed the presence of microplastic in human lungs. There remains an unmet need to identify the biodistribution of microplastic after inhalation. In this study, we traced the biodistribution of inhaled micro-sized polystyrene (mPS) and/or nano-sized PS (nPS) using ⁶⁴Cu with PET in mice.

Methods

We used 0.2-0.3-µm sized mPS and 20-nm sized nPS throughout. ⁶⁴Cu-DOTA-mPS, ⁶⁴Cu-DOTA-nPS and/or ⁶⁴CuCl₂ were used to trace the distribution in the murine inhalation model. PET images were acquired using an INVEON PET scanner at 1, 12, 24, 48, and 72 h after intratracheal instillation, and the SUV_max for interesting organs were determined, biodistribution was then determined in terms of perce

SUBMITTER: Shanmugiah J 

PROVIDER: S-EPMC10829228 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature