Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression.

ABSTRACT:

Background

Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is identified as an oncogene involved in multiple regulation of tumor progression, but specific mechanisms remain unclear in cervical cancer. Lactate-mediated lactylation modulates protein function. Whether DCBLD1 can be modified by lactylation and the function of DCBLD1 lactylation are unknown. Therefore, this study aims to investigate the lactylation of DCBLD1 and identify its specific lactylation sites. Herein, we elucidated the mechanism by which lactylation modification stabilizes the DCBLD1 protein. Furthermore, we investigated DCBLD1 overexpression activating pentose phosphate pathway (PPP) to promote the progression of cervical cancer.

Methods

DCBLD1 expression was examined in human cervical cancer

SUBMITTER: Meng Q 

PROVIDER: S-EPMC10829273 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature