Identification the Low Oxidative Stress Subtype of Periodontitis.

ABSTRACT:

Objective

The aim of this research was to identify the low oxidative stress-related genes expression (L-OS) subtype in patients with periodontitis.

Methods

Microarray data (MA) were retrieved from the Gene Expression Omnibus database. The different oxidative stress (OS) subtypes of periodontitis were identified by K-means clustering analysis and gene set variation analysis (GSVA). Differentially expressed genes (DEGs) (|Log fold change (FC)| >1, q < 0.05) amongst the OS subtypes and healthy controls (HCs) were identified by Limma R package. The genomic feature of L-OS subtype and corresponding medicines were evaluated and visualised with Drug-Gene Interaction Database and cytoscape-v3.7.2 software (Pearson correlation coefficient > 0.4). Finally, the LASSO-Logistic regressio

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10829343 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature