Differential effects of cholesterol levels on cognition according to body mass index in Parkinson's disease.

ABSTRACT:

Background

Cholesterol is an essential component of the neuronal cell membrane and is crucial for neuronal function; however, the role of cholesterol levels in Parkinson's disease (PD) is debatable. This study investigated the complex relationship between total cholesterol (TC) levels, body mass index (BMI), and cognition in patients with PD.

Methods

This study included 321 drug-naïve patients with PD who underwent dopamine transporter (DAT) imaging and baseline neuropsychological tests. Multivariate linear regression and Cox regression models were used to investigate the effect of TC levels on the composite score of each cognitive domain and dementia conversion after adjusting for covariates, respectively. Interaction analyses were performed to examine the interaction effec

SUBMITTER: Jeong SH 

PROVIDER: S-EPMC10829366 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature