Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization.

ABSTRACT: The osteoimmune microenvironment induced by implants plays a significant role in bone regeneration. It is essential to efficiently and timely switch the macrophage phenotype from M1 to M2 for optimal bone healing. This study examined the impact of a calcium phosphate (CaP) coating on the physiochemical properties of highly ordered polycaprolactone (PCL) scaffolds fabricated using melt electrowritten (MEW). Additionally, it investigated the influence of these scaffolds on macrophage polarization and their immunomodulation on osteogenesis. The results revealed that the CaP coated PCL scaffold exhibited a rougher surface topography and higher hydrophilicity in comparison to the PCL scaffold without coating. Besides, the surface morphology of the coating and the release of Ca²⁺ from

SUBMITTER: Shi Y 

PROVIDER: S-EPMC10829397 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature