Caveolin-1, a Determinant of the Fate of MCF-7 Breast Cancer Cells.

ABSTRACT:

Background

The scaffolding protein, caveolin-1 (Cav-1), participates in multiple cellular functions including promotion of sodium excretion from the kidney. Loss of expression of Cav-1 is associated with tumorigenesis of various types of cancer. We have shown the potential link between hypertension and breast cancer via abnormal function of the G protein-coupled receptor kinase type 4 (GRK4).

Objective

The current studies tested the hypothesis that Cav-1 acts as a tumor-suppressive factor in breast cancer cells and enhances the sensitivity to the inhibitory effect of the type 1 dopaminergic receptor (D₁R).

Methods

Michigan Cancer Foundation (MCF) MCF-7 cells stably expressing a Cav-1/mCherry fusion protein or mCherry alone were used as models to examine the

SUBMITTER: Chai T 

PROVIDER: S-EPMC10829489 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature