Microbiome Profiling in Bladder Cancer Patients Using the First-morning Urine Sample.

ABSTRACT:

Background

Several studies support the interplay between the urinary microbiome (ie, urobiome) and bladder cancer (BCa). Specific urinary bacteria may be responsible for chronic inflammation, which in turn promotes carcinogenesis. Different signatures of urobiome in BCa patients were identified depending on tumor type, geographical area, age, and sex.

Objective

We explored the urobiome in BCa patients undergoing transurethral resection of bladder tumor (TURBT), to identify possible predictive biomarkers of cancer.

Design setting and participants

The urobiome analysis was conducted in 48 patients (13 females) undergoing TURBT, of whom 30 with BCa (five females) and 18 with benign bladder tumor, analyzing bacterial 16S rRNA by next-generation sequencing in first-morning

SUBMITTER: Nardelli C 

PROVIDER: S-EPMC10829607 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature