Molecular pathology assists the diagnosis of lymphoepithelial sialadenitis, Sjogren's syndrome and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue.

ABSTRACT:

Background/purpose

Lymphoepithelial sialadenitis (LESA), Sjögren's syndrome (SS), and salivary MALT lymphoma are diseases characterized by lymphoepithelial lesions, and the differential diagnosis between them in the salivary glands is challenging. This study aimed to explore clinicopathological and genetic characteristics of the three diseases.

Materials and methods

We retrospectively analyzed the clinical features, the histomorphology, immunohistochemistry, and genetic profiling by polymerase chain reaction (PCR) and next-generation sequencing (NGS).

Results

There included 68 LESAs, 25 SSs, and 62 MALT lymphomas. Ten cases relapsed in total, and 3 of MALT lymphomas died due to high-level transformation. Immunohistochemical double staining showed FCRL4 cells co-expres

SUBMITTER: Chi Y 

PROVIDER: S-EPMC10829612 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature