The Impact of Chronic Phthalate Exposure on Rodent Anxiety and Cognition.

ABSTRACT:

Background

There is a growing importance for environmental contributions to psychiatric disorders and understanding the impact of the exposome (i.e., pollutants and toxins). For example, increased biomonitoring and epidemiological studies suggest that daily phthalate chemical exposure contributes to neurological and behavioral abnormalities; however, these mechanisms remain poorly understood. Therefore, the current study was aimed at examining the effects of chronic phthalate exposure on rodent anxiety behaviors and cognition and the impact on hypothalamic-pituitary-adrenal axis function.

Methods

Adult male mice (C57BL6/J) were administered MEHP via drinking water (1 mg/mL), and anxiety-like behavior and cognition combined with hypothalamic-pituitary-adrenal axis and inflamm

SUBMITTER: Yu Z 

PROVIDER: S-EPMC10829632 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature