Functional Connectivity Between Auditory and Medial Temporal Lobe Networks in Antipsychotic-Naive Patients With First-Episode Schizophrenia Predicts the Effects of Dopamine Antagonism on Auditory Verbal Hallucinations.

ABSTRACT:

Background

Understanding how antipsychotic medication ameliorates auditory verbal hallucinations (AVHs) through modulation of brain circuitry is pivotal for understanding the pathophysiology of psychosis and for predicting treatment response.

Methods

This case-control study included examinations at baseline and at follow-up after 6 weeks. Initially, antipsychotic-naïve patients with first-episode schizophrenia who were experiencing AVHs were recruited together with healthy control participants. Antipsychotic treatment with the relatively selective D₂ receptor antagonist amisulpride was administered as monotherapy. Functional connectivity measured by resting-state functional magnetic resonance imaging between networks of interest was used to study the effects of D<

SUBMITTER: Anhoj S 

PROVIDER: S-EPMC10829637 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature