Neurobehavioral Precursors of Compulsive Cocaine Seeking in Dual Frontostriatal Circuits.

ABSTRACT:

Background

Only some individuals who use drugs recreationally eventually develop a substance use disorder, characterized in part by the rigid engagement in drug foraging behavior (drug seeking), which is often maintained in the face of adverse consequences (i.e., is compulsive). The neurobehavioral determinants of this individual vulnerability have not been fully elucidated.

Methods

Using a prospective longitudinal study involving 39 male rats, we combined multidimensional characterization of behavioral traits of vulnerability to stimulant use disorder (impulsivity and stickiness) and resilience (sign tracking and sensation seeking/locomotor reactivity to novelty) with magnetic resonance imaging to identify the structural and functional brain correlates of the later emergenc

SUBMITTER: Jones JA 

PROVIDER: S-EPMC10829640 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature