Corticosteroid Treatment During Sepsis Alters Hippocampal Function in Male and Female Survivors.

ABSTRACT:

Background

Millions of sepsis survivors annually face neuropsychiatric sequelae of their illness. Corticosteroids are frequently administered for sepsis, and their use improves neuropsychiatric outcomes, but the mechanisms are unknown. In light of prior work that has shown persistent inflammation in sepsis survivors, we hypothesized that short-term corticosteroid treatment during illness would reverse the long-term impact of sepsis on inflammatory gene expression in the hippocampus and rescue associated changes to affective behaviors.

Methods

Male and female mice underwent cecal ligation and puncture or a sham surgery to induce acute infection and were treated for 5 days with corticosterone or vehicle. Starting 2 weeks after the surgery, we performed functional phenotyping i

SUBMITTER: Hill A 

PROVIDER: S-EPMC10829652 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature