Phencyclidine Disrupts Neural Coordination and Cognitive Control by Dysregulating Translation.

ABSTRACT:

Background

Phencyclidine (PCP) causes psychosis, is abused with increasing frequency, and was extensively used in antipsychotic drug discovery. PCP discoordinates hippocampal ensemble action potential discharge and impairs cognitive control in rats, but how this uncompetitive NMDA receptor (NMDAR) antagonist impairs cognition remains unknown.

Methods

The effects of PCP were investigated on hippocampal CA1 ensemble action potential discharge in vivo in urethane-anesthetized rats and during awake behavior in mice, on synaptic responses in ex vivo mouse hippocampus slices, in mice on a hippocampus-dependent active place avoidance task that requires cognitive control, and on activating the molecular machinery of translation in acute hippocampus slices. Mechanistic causality was

SUBMITTER: Park EH 

PROVIDER: S-EPMC10829677 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature