Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults.

ABSTRACT:

Background

Safety signal learning (SSL), based on conditioned inhibition of fear in the presence of learned safety, can effectively attenuate threat responses in animal models and humans. Difficulty regulating threat responses is a core feature of anxiety disorders, suggesting that SSL may provide a novel mechanism for fear reduction. Cross-species evidence suggests that SSL involves functional connectivity between the anterior hippocampus and the dorsal anterior cingulate cortex. However, the neural mechanisms supporting SSL have not been examined in relation to trait anxiety or while controlling for the effect of novelty.

Methods

Here, we investigated the neural mechanisms involved in SSL and associations with trait anxiety in a sample of 64 healthy (non-clinically anxious

SUBMITTER: Odriozola P 

PROVIDER: S-EPMC10829678 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature