Anti-S-layer monoclonal antibodies impact <i>Clostridioides difficile</i> physiology.

ABSTRACT: Clostridioides difficile (C. difficile), a gram-positive anaerobic and spore-forming bacterium, is the leading cause of nosocomial antibiotic-associated diarrhea in adults which is characterized by high levels of recurrence and mortality. Surface (S)-layer Protein A (SlpA), the most abundantly expressed protein on the bacterial surface, plays a crucial role in the early stages of infection although the nature of its involvement in C. difficile physiology is yet to be fully understood. Anti-S-layer antibodies have been identified in the sera of convalescent patients and have been correlated with improved outcomes of C. difficile infection (CDI). However, the precise mechanisms by which anti-S-layer antibodies confer protection to the host remain unknown. In this

SUBMITTER: Hunault L 

PROVIDER: S-EPMC10829821 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature