The effectiveness of acellular nerve allografts compared to autografts in animal models: A systematic review and meta-analysis.

ABSTRACT:

Background

Treatment of nerve injuries proves to be a worldwide clinical challenge. Acellular nerve allografts are suggested to be a promising alternative for bridging a nerve gap to the current gold standard, an autologous nerve graft.

Objective

To systematically review the efficacy of the acellular nerve allograft, its difference from the gold standard (the nerve autograft) and to discuss its possible indications.

Material and methods

PubMed, Embase and Web of Science were systematically searched until the 4th of January 2022. Original peer reviewed paper that presented 1) distinctive data; 2) a clear comparison between not immunologically processed acellular allografts and autologous nerve transfers; 3) was performed in laboratory animals of all species and sex. Me

SUBMITTER: Broeren BO 

PROVIDER: S-EPMC10829984 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature