Genome-wide analyses reveal the contribution of somatic variants to the immune landscape of multiple cancer types.

ABSTRACT: It has been well established that cancer cells can evade immune surveillance by mutating themselves. Understanding genetic alterations in cancer cells that contribute to immune regulation could lead to better immunotherapy patient stratification and identification of novel immune-oncology (IO) targets. In this report, we describe our effort of genome-wide association analyses across 22 TCGA cancer types to explore the associations between genetic alterations in cancer cells and 74 immune traits. Results showed that the tumor microenvironment (TME) is shaped by different gene mutations in different cancer types. Out of the key genes that drive multiple immune traits, top hit KEAP1 in lung adenocarcinoma (LUAD) was selected for validation. It was found that KEAP1 mutations can explain more t

SUBMITTER: Bi W 

PROVIDER: S-EPMC10829993 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature