African American race does not confer an increased risk of clinical events in patients with primary sclerosing cholangitis.

ABSTRACT:

Background

The natural history of primary sclerosing cholangitis (PSC) among African Americans (AA) is not well understood.

Methods

Transplant-free survival and hepatic decompensation-free survival were assessed using a retrospective research registry from 16 centers throughout North America. Patients with PSC alive without liver transplantation after 2008 were included. Diagnostic delay was defined from the first abnormal liver test to the first abnormal cholangiogram/liver biopsy. Socioeconomic status was imputed by the Zip code.

Results

Among 850 patients, 661 (77.8%) were non-Hispanic Whites (NHWs), and 85 (10.0%) were AA. There were no significant differences by race in age at diagnosis, sex, or PSC type. Inflammatory bowel disease was more common in NHWs (75.8%

SUBMITTER: Yazdanfar M 

PROVIDER: S-EPMC10830082 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature