Stereodivergent 1,3-difunctionalization of alkenes by charge relocation.

ABSTRACT: Alkenes are indispensable feedstocks in chemistry. Functionalization at both carbons of the alkene-1,2-difunctionalization-is part of chemistry curricula worldwide¹. Although difunctionalization at distal positions has been reported^2-4, it typically relies on designer substrates featuring directing groups and/or stabilizing features, all of which determine the ultimate site of bond formation^5-7. Here we introduce a method for the direct 1,3-difunctionalization of alkenes, based on a concept termed 'charge relocation', which enables stereodivergent access to 1,3-difunctionalized products of either syn- or anti-configuration from unactivated alkenes, without the need for directing groups or stabilizing features. The usefulness of the approach is demonstrated

SUBMITTER: Brutiu BR 

PROVIDER: S-EPMC10830407 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature