Autoreactive T cells target peripheral nerves in Guillain-Barre syndrome.

ABSTRACT: Guillain-Barré syndrome (GBS) is a rare heterogenous disorder of the peripheral nervous system, which is usually triggered by a preceding infection, and causes a potentially life-threatening progressive muscle weakness¹. Although GBS is considered an autoimmune disease, the mechanisms that underlie its distinct clinical subtypes remain largely unknown. Here, by combining in vitro T cell screening, single-cell RNA sequencing and T cell receptor (TCR) sequencing, we identify autoreactive memory CD4⁺ cells, that show a cytotoxic T helper 1 (T_H1)-like phenotype, and rare CD8⁺ T cells that target myelin antigens of the peripheral nerves in patients with the demyelinating disease variant. We characterized more than 1,000 autoreactive single T cell clon

SUBMITTER: Sukenikova L 

PROVIDER: S-EPMC10830418 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature