Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines.

ABSTRACT:

Introduction

A reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.

Methods<

SUBMITTER: Shin HY 

PROVIDER: S-EPMC10830637 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature