Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain.

ABSTRACT: Glucocorticoids are key executors of the physiological response to stress. Previous studies in mice showed that the androgen receptor (AR) influenced the transcriptional outcome of glucocorticoid treatment in white and brown adipocytes and in the liver. In the brain, we observed that chronic hypercorticism induced changes in gene expression that tended to be more pronounced in male mice. In the present study, we investigated if glucocorticoid signaling in the brain could be modulated by androgen. After chronic treatment with corticosterone, dihydrotestosterone, a combination of both, and corticosterone in combination with the AR antagonist enzalutamide, we compared the expression of glucocorticoid receptor (NR3C1, also abbreviated GR) target genes in brain regions where AR and GR are co-ex

SUBMITTER: Amaya JM 

PROVIDER: S-EPMC10830692 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature