Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome.

ABSTRACT:

Introduction

A group of SARS-CoV-2 infected individuals present lingering symptoms, defined as long COVID (LC), that may last months or years post the onset of acute disease. A portion of LC patients have symptoms similar to myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), which results in a substantial reduction in their quality of life. A better understanding of the pathophysiology of LC, in particular, ME/CFS is urgently needed.

Methods

We identified and studied metabolites and soluble biomarkers in plasma from LC individuals mainly exhibiting ME/CFS compared to age-sex-matched recovered individuals (R) without LC, acute COVID-19 patients (A), and to SARS-CoV-2 unexposed healthy individuals (HC).

Results

Through these analyses, we identified alterati

SUBMITTER: Saito S 

PROVIDER: S-EPMC10830702 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature