Ultrasonic cavitation induced Vibrio parahaemolyticus entering an apoptosis-like death process through SOS response.

ABSTRACT: As an effective non-thermal sterilization method, ultrasound remains at the level of passive bacterial death despite the initial understanding of its sterilization mechanism. Here, we present the perspective that bacteria can choose to actively enter an apoptosis-like death state in response to external ultrasonic stress. In this study, Vibrio parahaemolyticus exhibited apoptotic markers such as phosphatidylserine ectropion and activated caspases when subjected to ultrasound stress. Additionally, the accumulation of reactive oxygen species (ROS) and enhanced calcium signaling were observed. Further transcriptomic analysis was conducted to investigate the regulatory mechanism of the SOS response in Vibrio parahaemolyticus during an apoptosis-like state. The results showed that the genes enc

SUBMITTER: Liu C 

PROVIDER: S-EPMC10830854 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature