Bioinformatics reveals the pathophysiological relationship between diabetic nephropathy and periodontitis in the context of aging.

ABSTRACT: Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Periodontitis (PD) is a microbially-induced chronic inflammatory disease that is thought to have a bidirectional relationship with diabetes mellitus. DN and PD are recognized as models associated with accelerated aging. This study is divided into two parts, the first of which explores the bidirectional causal relationship through Mendelian randomization (MR). The second part aims to investigate the relationship between PD and DN in terms of potential crosstalk genes, aging-related genes, biological pathways, and processes using bioinformatic methods. MR analysis showed no evidence to support a causal relationship between DN and PD (P = 0.34) or PD and DN (P = 0.77). Using the

SUBMITTER: Yan P 

PROVIDER: S-EPMC10830875 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature