Repeatability of [¹⁵O]H₂O PET imaging for lower extremity skeletal muscle perfusion: a test-retest study.

ABSTRACT:

Background

[¹⁵O]H₂O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis and treatment of peripheral artery disease. We aimed to evaluate the reliability of dynamic [¹⁵O]H₂O PET imaging for measuring lower extremity skeletal muscle perfusion. Ten healthy participants underwent same-day test-retest study with six dynamic [¹⁵O]H₂O PET scans of lower legs and feet. Manual volume-of-interests were drawn in skeletal muscles, and PET time activity curves were extracted. K₁ values (mL/min/100 mL) were estimated using a single-tissue compartment model (1TCM), autoradiography (ARG), and parametric imaging with blood input functions obtained from separa

SUBMITTER: Christensen NL 

PROVIDER: S-EPMC10830956 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature