Characterization of hypoxia-responsive states in ovarian cancer to identify hot tumors and aid adjuvant therapy.

ABSTRACT:

Backgrounds

The hypoxia-responsive state of cancer is a complex pathophysiological process involving numerous genes playing different roles. Due to the rapid proliferation of cancer cells and chaotic angiogenesis, the clinical features of hypoxia-responsive states are not yet clear in patients with ovarian cancer.

Methods

Based on the RNA expression levels of 14 hypoxic markers, our study screened out hypoxia-related genes and construct a hypoxic score pattern to quantify the hypoxia-responsive states of a single tumor. Combining clinical prognosis, tumor mutation burden, microsatellite instability, the expression level of the immune checkpoint, IC50, and other indicators to evaluate the impact of different hypoxia-responsive states on clinical prognosis and therapeutic sens

SUBMITTER: Cao M 

PROVIDER: S-EPMC10831007 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature