Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry.

ABSTRACT: Patients with drug-resistant essential tremor (ET) may undergo Gamma Knife stereotactic radiosurgical thalamotomy (SRS-T), where the ventro-intermediate nucleus of the thalamus (Vim) is lesioned by focused beams of gamma radiations to induce clinical improvement. Here, we studied SRS-T impacts on left Vim dynamic functional connectivity (dFC, n = 23 ET patients scanned before and 1 year after intervention), and on surface-based morphometric brain features (n = 34 patients, including those from dFC analysis). In matched healthy controls (HCs), three dFC states were extracted from resting-state functional MRI data. In ET patients, state 1 spatial stability increased upon SRS-T (F_1,22 = 19.13, p = 0.004). More frequent expression of state 3 over state 1 before SRS-T correlated with

SUBMITTER: Bolton TAW 

PROVIDER: S-EPMC10831051 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature