PET-CT-guided versus CT-guided biopsy in suspected malignant pleural thickening: a randomised trial.

ABSTRACT:

Background

Pleural biopsy is the gold standard for diagnosis of pleural malignancy but a significant proportion will have an inconclusive biopsy despite ongoing clinical suspicion of malignancy. We investigated whether positron emission tomography-computed tomography (PET-CT) targeted pleural biopsy is superior to standard CT-guided pleural biopsy following an initial non-diagnostic biopsy.

Methods

The TARGET trial was a multicentre, parallel group randomised trial. Patients with a previous inconclusive pleural biopsy but an ongoing suspicion of pleural malignancy were randomised (1:1) to receive either CT-guided biopsy (standard care) or PET-CT followed by a targeted CT biopsy (intervention). The primary outcome was pleural malignancy correctly identified from the trial bio

SUBMITTER: de Fonseka D 

PROVIDER: S-EPMC10831139 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature