Effects of nintedanib on symptoms in patients with progressive pulmonary fibrosis.

ABSTRACT:

Background

Dyspnoea and cough can have a profound impact on the lives of patients with pulmonary fibrosis. We investigated the effects of nintedanib on the symptoms and impact of pulmonary fibrosis in patients with progressive pulmonary fibrosis (PPF) in the INBUILD trial using the Living with Pulmonary Fibrosis (L-PF) questionnaire.

Methods

Patients had a fibrosing interstitial lung disease (ILD) (other than idiopathic pulmonary fibrosis) of >10% extent on high-resolution computed tomography (HRCT) and met criteria for ILD progression within the prior 24 months. Patients were randomised 1:1 to receive nintedanib or placebo. Changes in L-PF questionnaire scores from baseline to week 52 were assessed using mixed models for repeated measures.

Results

In total, 663 patie

SUBMITTER: Wijsenbeek M 

PROVIDER: S-EPMC10831140 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature