Characterizing the West Nile Virus's polyprotein from nucleotide sequence to protein structure - Computational tools.

ABSTRACT:

Objectives

West Nile virus (WNV) belongs to the Flaviviridae family and causes West Nile fever. The mechanism of transmission involves the culex mosquito species. Infected individuals are primarily asymptomatic, and few exhibit common symptoms. Moreover, 10 % of neuronal infection caused by this virus cause death. The proteins encoded by these genes had been uncharacterized, although understanding their function and structure is important for formulating antiviral drugs.

Methods

Herein, we used in silico approaches, including various bioinformatic tools and databases, to analyse the proteins from the WNV polyprotein individually. The characterization included GC content, physicochemical properties, conserved domains, soluble and transmembrane regions, signal localization, pr

SUBMITTER: Praveen M 

PROVIDER: S-EPMC10831166 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature