Biostable hydrogels consisting of hybrid β-sheet fibrils assembled by a pair of enantiomeric peptides.

ABSTRACT: The assembly of chiral peptides facilitates the formation of diverse supramolecular structures with unique physicochemical and biological properties. However, the effects of chirality on peptide assembly and resulting hydrogel properties remain underexplored. In this study, we systematically investigated the assembly propensity, morphology, and biostability of mixture of a pair of enantiomeric peptides ^LE^LC^LA^LF^LF (ECF-5) and ^DE^DC^DA^DF^DF (ecf-5) at various ratios. Results indicate the development of β-sheet fibrils, ultimately leading to the formation of self-supporting hybrid hydrogels. The hydrogel formed at a ratio of 1:1 exhibits a significantly lower storage modulus (G') than of

SUBMITTER: Tan T 

PROVIDER: S-EPMC10831280 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature