Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides.

ABSTRACT: The regulation of cellular processes by ion channels has become central to the study of cancer mechanisms. Designing molecules that can modify ion channels specific to tumor cells is a promising area of targeted drug delivery and therapy. Despite their potential in drug discovery, venom peptides-a group of natural products-have largely remained understudied and under-characterized. In general, venom peptides display high specificity and selectivity for their target ion channels. Therefore, they may represent an effective strategy for selectively targeting the dysregulation of ion channels in tumor cells. This review examines existing venom peptide therapies for different cancer types and focuses on the application of snail venom peptides in hepatocellular carcinoma (HCC), the most common f

SUBMITTER: Achimba F 

PROVIDER: S-EPMC10831335 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature