Phenols and GABA_A receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae.

ABSTRACT: γ-Aminobutyric acid type A receptors (GABA_ARs) are members of the pentameric ligand-gated ion channel (pLGIC) family, which are widespread throughout the invertebrate and vertebrate central nervous system. GABA_ARs are engaged in short-term changes of the neuronal concentrations of chloride (Cl^-) and bicarbonate (HCO₃ ^-) ions by their passive permeability through the ion channel pore. GABA_ARs are regulated by various structurally diverse phenolic substances ranging from simple phenols to complex polyphenols. The wide chemical and structural variability of phenols suggest similar and different binding sites on GABA_ARs, allowing them to manifest themselves as activators, inhibitors, or allosteric ligands of GABA

SUBMITTER: Menzikov SA 

PROVIDER: S-EPMC10831359 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature