Large overlap in neutrophil transcriptome between lupus and COVID-19 with limited lupus-specific gene expression.

ABSTRACT:

Objectives

To illuminate the poorly understood aetiology of SLE by comparing the gene expression profile of SLE neutrophils with that of neutrophils from patients infected by SARS-CoV-2, a disease (COVID-19) with well-defined antigens and a similar type I interferon response.

Methods

RNA sequencing of neutrophils from patients with SLE (n=15) and healthy controls (n=12) was analysed for differential gene expression and modulated pathways. The same analyses were performed on a similar neutrophil dataset from patients with SARS-CoV-2 infection (n=30) and healthy controls (n=8). Next, we carried out comparative analyses to identify common and unique transcriptional changes between the two disease contexts, emphasising genes regulated in opposite directions.

Results

We id

SUBMITTER: Najjar R 

PROVIDER: S-EPMC10831459 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature