Real-world practice patterns and outcomes for RAI-refractory differentiated thyroid cancer.

ABSTRACT:

Background

The optimal timing for initiating multi-kinase inhibitors (MKIs) in patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC) remains unclear. Thus, we evaluated the real-world practice patterns and outcomes in asymptomatic patients with progressive RAI-R DTC (≥1 lesion ≥1 cm in diameter) in the USA (US population) and outside the USA (non-US population).

Methods

In this prospective, non-interventional, open-label study, eligible patients were chosen by treating physicians to receive MKI therapy (cohort 1) or undergo active surveillance (cohort 2) at study entry. Cohort 2 patients were allowed to transition to MKI therapy later. The primary endpoint was time to symptomatic progression (TTSP) from study entry. Data were compared descri

SUBMITTER: Gianoukakis AG 

PROVIDER: S-EPMC10831529 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature