Respiratory viral detection in the plasma and cerebrospinal fluid (CSF) of young febrile infants.

ABSTRACT:

Background

Respiratory viral infections are common in febrile infants ≤90 days. However, the detection of viruses other than enterovirus in the blood and cerebrospinal fluid (CSF) of young infants is not well defined. We sought to quantify the occurrence of respiratory viruses in the blood and CSF of febrile infants ≤90 days.

Methods

We conducted a nested cohort study examining plasma and CSF samples from febrile infants 15-90 days via rtPCR. The samples were tested for respiratory viruses (respiratory syncytial virus, influenza, enterovirus, parechovirus, adenovirus, bocavirus). Clinical and laboratory data were also collected to determine the presence of serious bacterial infections (SBI).

Results

Twenty-four percent (30 of 126) of infants had plasma/CSF specimens p

SUBMITTER: Nicholson EG 

PROVIDER: S-EPMC10831571 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature