Novel insights on genetics and epigenetics as clinical targets for paediatric astrocytoma.

ABSTRACT: Paediatric and adult astrocytomas are notably different, where clinical treatments used for adults are not as effective on children with the same form of cancer and these treatments lead to adverse long-term health concerns. Integrative omics-based studies have shown the pathology and fundamental molecular characteristics differ significantly and cannot be extrapolated from the more widely studied adult disease. Recent clinical advances in our understanding of paediatric astrocytomas, with the aid of next-generation sequencing and epigenome-wide profiling, have led to the identification of key canonical mutations that vary based on the tumour location and age of onset. These driver mutations, in particular the identification of the recurrent histone H3 mutations in high-grade tumours, have

SUBMITTER: Johns DA 

PROVIDER: S-EPMC10831580 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature