Influence of pancreaticoduodenectomy for periampullary carcinoma on intestinal microbiome and metabolites.

ABSTRACT: Recent growing evidence suggests a role for intestinal microbiome and metabolites in patients' postoperative recovery. Therefore, there is a need to gain insight into the impact of pancreaticoduodenectomy for periampullary carcinoma on microbiome and metabolites and the potential impact of their changes on patients' condition. Based on 16S rDNA gene sequencing and untargeted metabolomic analysis, we found that the diversity and abundance of intestinal microbiome were significantly higher in patients preoperatively than postoperatively, and the level of intestinal probiotics was significantly lower after surgery compared with preoperatively. In addition, the choline metabolism level was increased and the amino acid metabolism level was decreased after surgery. A total of 53 differential mic

SUBMITTER: Fang J 

PROVIDER: S-EPMC10831615 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature