Dual-energy CT-based radiomics in predicting EGFR mutation status non-invasively in lung adenocarcinoma.

ABSTRACT:

Objectives

Patients with epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma (LUAD) can benefit from individualized targeted therapy. This study aims to develop, compare, analyse prediction models based on dual-energy spectral computed tomography (DESCT) and CT-based radiomic features to non-invasively predict EGFR mutation status in LUAD.

Materials and methods

Patients with LUAD (n = 175), including 111 patients with and 64 patients without EGFR mutations, were enrolled in the current study. All patients were randomly divided into a training dataset (122 cases) and validation dataset (53 cases) at a ratio of 7:3. After extracting CT-based radiomic, DESCT and clinical features, we built seven prediction models and a nomogram of the best prediction. Recei

SUBMITTER: Ma JW 

PROVIDER: S-EPMC10831617 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature