Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators.

ABSTRACT:

Background/objective

(1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms.

Method

This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE ε4 carrier status were explored as genetic moderators of exercise effects on mental he

SUBMITTER: Gujral S 

PROVIDER: S-EPMC10831729 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature