Elevated levels of serotonin 5-HT_2A receptors in the orbitofrontal cortex of antisocial individuals.

ABSTRACT: Antisocial behavior (ASB) is characterized by frequent violations of the rights and properties of others, as well as aggressive conduct. While ample evidence points to a critical role of serotonin in the emotional modulation of social responses, the implication of this neurotransmitter in ASB is unclear. Here, we performed the first-ever postmortem analysis of serotonergic markers in the orbitofrontal cortex (OFC) of male subjects with ASB (n = 9). We focused on this brain region, given its well-recognized role in social response and ASB pathophysiology. Given that all individuals also had a substance use disorder (SUD) diagnosis, two age-matched control groups were used: SUD only and unaffected controls. Tissues were processed for immunoblotting analyses on eight key serotonergic targets:

SUBMITTER: Braccagni G 

PROVIDER: S-EPMC10831872 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature