Dataset Information

Complementary feature learning across multiple heterogeneous networks and multimodal attribute learning for predicting disease-related miRNAs.

ABSTRACT: Inferring the latent disease-related miRNAs is helpful for providing a deep insight into observing the disease pathogenesis. We propose a method, CMMDA, to encode and integrate the context relationship among multiple heterogeneous networks, the complementary information across these networks, and the pairwise multimodal attributes. We first established multiple heterogeneous networks according to the diverse disease similarities. The feature representation embedding the context relationship is formulated for each miRNA (disease) node based on transformer. We designed a co-attention fusion mechanism to encode the complementary information among multiple networks. In terms of a pair of miRNA and disease nodes, the pairwise attributes from multiple networks form a multimodal attribute embedding. A module based on depthwise separable convolution is constructed to enhance the encoding of the specific features from each modality. The experimental results and the ablation studies show that CMMDA's superior performance and the effectiveness of its major innovations.

SUBMITTER: Xuan P

PROVIDER: S-EPMC10831890 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Complementary feature learning across multiple heterogeneous networks and multimodal attribute learning for predicting disease-related miRNAs.

Xuan Ping P Xiu Jinshan J Cui Hui H Zhang Xiaowen X Nakaguchi Toshiya T Zhang Tiangang T

iScience 20231205 2

Inferring the latent disease-related miRNAs is helpful for providing a deep insight into observing the disease pathogenesis. We propose a method, CMMDA, to encode and integrate the context relationship among multiple heterogeneous networks, the complementary information across these networks, and the pairwise multimodal attributes. We first established multiple heterogeneous networks according to the diverse disease similarities. The feature representation embedding the context relationship is f ...[more]

PMID: 38303724

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Project description:BackgroundThe association between MicroRNAs (miRNAs) and diseases is crucial in treating and exploring many diseases or cancers. Although wet-lab methods for predicting miRNA-disease associations (MDAs) are effective, they are often expensive and time-consuming. Significant advancements have been made using Graph Neural Network-based methods (GNN-MDAs) to address these challenges. However, these methods still face limitations, such as not considering nodes' deep-level similarity associations and hierarchical learning patterns. Additionally, current models do not retain the memory of previously learned heterogeneous historical information about miRNAs or diseases, only focusing on parameter learning without the capability to remember heterogeneous associations.ResultsThis study introduces the K-means disentangled high-level biological similarity to utilize potential hierarchical relationships fully and proposes a Graph Attention Heterogeneous Biological Memory Network architecture (DiGAMN) with memory capabilities. Extensive experiments were conducted across four datasets, comparing the DiGAMN model and its disentangling method against ten state-of-the-art non-disentangled methods and six traditional GNNs. DiGAMN excelled, achieving AUC scores of 96.35%, 96.10%, 96.01%, and 95.89% on the Data1 to Data4 datasets, respectively, surpassing all other models. These results confirm the superior performance of DiGAMN and its disentangling method. Additionally, various ablation studies were conducted to validate the contributions of different modules within the framework, and's encoding statuses and memory units of DiGAMN were visualized to explore the utility and functionality of its modules. Case studies confirmed the effectiveness of DiGAMN's predictions, identifying several new disease-associated miRNAs.ConclusionsDiGAMN introduces the use of a disentangled biological similarity approach for the first time and successfully constructs a Disentangled Graph Attention Heterogeneous Biological Memory Network model. This network can learn disentangled representations of similarity information and effectively store the potential biological entanglement information of miRNAs and diseases. By integrating disentangled similarity information with a heterogeneous attention memory network, DiGAMN enhances the model's ability to capture and utilize complex underlying biological data, significantly outperforming many existing models. The concepts used in this method also provide new perspectives for predicting miRNAs associated with diseases.

Dataset Information

Complementary feature learning across multiple heterogeneous networks and multimodal attribute learning for predicting disease-related miRNAs.

Publications

Complementary feature learning across multiple heterogeneous networks and multimodal attribute learning for predicting disease-related miRNAs.

Similar Datasets

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