Streamlined Chemo-Enzymatic Synthesis of Molnupiravir via Lipase Catalyst.

ABSTRACT: An enzymatic approach for the synthesis of Molnupiravir has been developed using immobilized lipase as a biocatalyst. This method involves a concise process of the regioselective esterification of uridine with isobutyric anhydride using Lipase (Addzyme-011). This efficient route gets 97% conversion of uridine 3, with an overall 73% yield of molnupiravir 1 in two steps. The use of inexpensive and easily available lipase makes the synthesis cost-effective and accessible globally, promoting the principles of green chemistry.

SUBMITTER: Rosangzuala K 

PROVIDER: S-EPMC10831972 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature